The Effect of Resistance Training on Serum Levels of NT-proBNP, GDF-15, and Markers of Cardiac Damage in the Elderly Males

Ebrahim Rangraz, Bahman Mirzaei, Farhad Rahmani Nia

International Journal of Applied Exercise Physiology
2322-3537 Vol.8 No.1

DOI: 10. 30472 /ijaep.v8i1.329

Resistance training (RT) has beneficial effects on the cardiovascular (CV) system and potentially can be an effective treatment for a variety of clinical conditions, such as heart disease (HD). However, the impacts of RT on cardiac risk factors in older men are less known .The current study was investigated the effect of RT on serum levels of NT-proBNP, GDF-15, and markers of cardiac damage (CK and CK-MB) in the elderly men.

24 elderly men (aged 72.1 ± 5.3 years, height 164.3 ± 5.5 cm, and BMI 27.2 ± 4.3 kg/m2 ) were randomly assigned to one of the two intervention groups: RT (n=12) and control (n=12). The RT protocol included eight movements (3 × 10 repetitions with ∼70% of one repetition maximum [1RM], 1-min rest intervals) for eight weeks and three sessions per week. Serum levels of NT-proBNP, GDF-15, CK and CK-MB were tested at baseline as well as after eight weeks of intervention. All analyses were performed with SPSS version 24 at a significance level of P≤ 0.05. Serum levels of NT-proBNP significantly decreased in the RT group after 8 weeks (p≤0.05). Moreover, resistance training significantly increased serum
levels of CK and CK-MB (p≤0.05). However, GDF-15 changes were not significant after eight weeks of RT (p>0.05). Therefore, our data confirm that resistance training May be improve cardiac risk factors in older men.

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